1. #1
    Rikie's Avatar
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    Worm Watch Lab (help de wetenschap)

    Worm Watch Lab

    Our small distant cousins
    We watch movies of the nematode worm C. elegans to understand how the brain works and how genes affect behaviour. The idea is that if a gene is involved in a visible behaviour, then mutations that break that gene might lead to detectable behavioural changes. The type of change gives us a hint about what the affected gene might be doing. Although it is small and has far fewer cells than we do, C. elegans has almost as many genes and because we share a common ancestor even with worms, many of them are closely related to human genes. This presents us with the opportunity to study the function of genes that are important for human brain function in an animal that is easier to handle, great for microscopy and genetics, and has a generation time of only a few days.

    The Importance of Egg Laying
    Egg laying in C. elegans requires the proper functioning of a neural circuit to activate the muscles that open the vulva to expel eggs. This circuit is modulated by a neurotransmitter called serotonin; the same molecule that affects mood in humans. Antidepressants like prozac work by stimulating serotonergic signaling in humans. They also work in worms and they stimulate egg laying! If we observe a mutant that lays more or fewer eggs than normal, this is a hint that something has gone wrong in the egg laying neural circuit or muscles and this can have far reaching implications, maybe even teaching us something about genes involved in depression in humans. The challenge is that there are thousands of genes without a known function and screening for worms with egg laying defects is time consuming. That's why we need your help!

    Worm Tracking
    We have built tracking microscopes to record video of crawling worms. A USB microscope is mounted on a motorised stage connected to a computer. When the worm moves, the computer analyses the changing image and commands the stage to move to re-centre the worm in the field of view. Because the trackers work without supervision, we can run eight of them in parallel to collect a lot of movies. If you'd like to learn more about worm tracking (or even build a tracker yourself!), we have a parts list and instructions on our tracking website
    TL/DR: Help de wetenschap door wormen te bestuderen.
    Je krijgt een fragment van 30 seconden te zien van een rondkruipende worm. Als deze eitjes legt moet je deze registeren. Deze gegevens zouden ons kunnen helpen om de werking van onze genen beter te begrijpen.
    "The creatures outside looked from pig to man, and from man to pig, and from pig to man again; but already it was impossible to say which was which."
    ~ George Orwell, Animal Farm

    Youri Tielemans - Anthony Vanden Borre - Matias Suarez - Lucas Biglia - Dieumerci Mbokani

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  2. #2

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    Heb 10 filmpjes gezien, niks gezien van ei-legging ofwel is het gewoon niet zo duidelijk als op dat instructiefilmpje
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  3. #3
    Bontus's Avatar
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    Mijn eerste worm die legde veel eieren.
    Sindsdien niet veel soeps meer.
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  4. #4
    Rikie's Avatar
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    It is rare to see an egg. Most videos won't have anything to mark, so don't feel as if you are doing something wrong if you go a few videos not marking anything.
    Ik heb er ook maar 2 op 20 gehad ofzo.
    Wel één die er al minstens 10 had.
    "The creatures outside looked from pig to man, and from man to pig, and from pig to man again; but already it was impossible to say which was which."
    ~ George Orwell, Animal Farm

    Youri Tielemans - Anthony Vanden Borre - Matias Suarez - Lucas Biglia - Dieumerci Mbokani

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  5. #5
    glashelder's Avatar
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    Ah, Zooniverse Die hebben nog meer zo'n projectjes. Da's wel eens interessant om hun website te bekijken, ze hebben veel verschillende dingen waar je aan kan meehelpen. Ik ben ooit begonnen met logboeken van schepen over te typen maar ik raakte direct al gefrustreerd omdat er iets niet duidelijk was
    "A confident people is not exclusive. A great religion affirms other religions. A great culture affirms other cultures. A great nation affirms other nations. A great individual affirms other individuals, validates the being-ness of others and the vitality." ~ Leonard Cohen
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